Alteration in Mir-21/PTEN Expression Modulates Gefitinib Resistance in Non-Small Cell Lung Cancer

Resistance to TKI treatment is a major obstacle in effective treatment of NSCLC. Besides EGFR mutation status, the mechanisms involved are largely unknown. Some evidence supports a role for microRNA 21 in modulating drug sensitivity of chemotherapy but its role in NSCLC TKI resistance still remains...

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Detalhes bibliográficos
Main Authors: Shen, Hua, Zhu, Fang, Liu, Jinyuan, Xu, Tongpeng, Pei, Dong, Wang, Rong, Qian, Yingying, Li, Qi, Wang, Lin, Shi, Zhumei, Zheng, Jitai, Chen, Qiudan, Jiang, Binghua, Shu, Yongqian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110008/
https://ncbi.nlm.nih.gov/pubmed/25058005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103305
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