Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders

BACKGROUND: Over the last decade, the transgenic N-methyl-D-aspartate receptor (NMDAR) NR1-knockdown mouse (NR1(neo−/−)) has been investigated as a glutamate hypofunction model for schizophrenia. Recent research has now revealed that the model also recapitulates cognitive and negative symptoms in th...

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Autori principali: Wesseling, Hendrik, Guest, Paul C, Lee, Chi-Ming, Wong, Erik HF, Rahmoune, Hassan, Bahn, Sabine
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109791/
https://ncbi.nlm.nih.gov/pubmed/25061506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2392-5-38
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