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Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents
Nuclear-cytoplasmic trafficking of proteins is a significant factor in the development of cancer and drug resistance. Subcellular localization of exported proteins linked to cancer development include those involved in cell growth and proliferation, apoptosis, cell cycle regulation, transformation,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108511/ https://ncbi.nlm.nih.gov/pubmed/24631834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2014.03.001 |
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