Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5

We report the identification and characterization of a five-carbon protein post-translational modification (PTM) called lysine glutarylation (K(glu)). This protein modification was detected by immunoblot and mass spectrometry (MS), and then comprehensively validated by chemical and biochemical metho...

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Bibliografiske detaljer
Main Authors: Tan, Minjia, Peng, Chao, Anderson, Kristin A., Chhoy, Peter, Xie, Zhongyu, Dai, Lunzhi, Park, Jeong Soon, Chen, Yue, Huang, He, Zhang, Yi, Ro, Jennifer, Wagner, Gregory R., Green, Michelle F., Madsen, Andreas S., Schmiesing, Jessica, Peterson, Brett S., Xu, Guofeng, Ilkayeva, Olga R., Muehlbauer, Michael J., Braulke, Thomas, Mühlhausen, Chris, Backos, Donald S., Olsen, Christian A., McGuire, Peter J., Pletcher, Scott D., Lombard, David B., Hirschey, Matthew D., Zhao, Yingming
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108075/
https://ncbi.nlm.nih.gov/pubmed/24703693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.014
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