Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5

We report the identification and characterization of a five-carbon protein post-translational modification (PTM) called lysine glutarylation (K(glu)). This protein modification was detected by immunoblot and mass spectrometry (MS), and then comprehensively validated by chemical and biochemical metho...

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Bibliografiska uppgifter
Huvudupphovsmän: Tan, Minjia, Peng, Chao, Anderson, Kristin A., Chhoy, Peter, Xie, Zhongyu, Dai, Lunzhi, Park, Jeong Soon, Chen, Yue, Huang, He, Zhang, Yi, Ro, Jennifer, Wagner, Gregory R., Green, Michelle F., Madsen, Andreas S., Schmiesing, Jessica, Peterson, Brett S., Xu, Guofeng, Ilkayeva, Olga R., Muehlbauer, Michael J., Braulke, Thomas, Mühlhausen, Chris, Backos, Donald S., Olsen, Christian A., McGuire, Peter J., Pletcher, Scott D., Lombard, David B., Hirschey, Matthew D., Zhao, Yingming
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108075/
https://ncbi.nlm.nih.gov/pubmed/24703693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.014
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