Structure and function study of the complex that synthesizes S-adenosylmethionine

S-Adenosylmethionine (SAMe) is the principal methyl donor of the cell and is synthesized via an ATP-driven process by methionine adenosyltransferase (MAT) enzymes. It is tightly linked with cell proliferation in liver and colon cancer. In humans, there are three genes, mat1A, mat2A and mat2B, which...

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Bibliografiske detaljer
Main Authors: Murray, Ben, Antonyuk, Svetlana V., Marina, Alberto, Van Liempd, Sebastiaan M., Lu, Shelly C., Mato, Jose M., Hasnain, S. Samar, Rojas, Adriana L.
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2014
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107924/
https://ncbi.nlm.nih.gov/pubmed/25075345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252514012585
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