p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

T-cell activation requires cooperative signals generated by the T-cell antigen receptor zeta-chain complex (TCR zeta-CD3) and the costimulatory antigen CD28. CD28 interacts with three intracellular proteins-phosphatidylinositol 3-kinase (PI 3-kinase), T cell-specific protein-tyrosine kinase ITK (for...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Raab, M, Cai, Y C, Bunnell, S C, Heyeck, S D, Berg, L J, Rudd, C E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568038/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8891
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!