Outpatient Bendamustine and Idarubicin for Upfront Therapy of Elderly acute myeloid leukaemia/myelodysplastic syndrome: A Phase I/II Study using an Innovative Statistical Design

Combinations of agents may improve outcomes among elderly acute myeloid leukaemia (AML) and high-risk myelodysplastic syndrome (MDS) patients. We performed an adaptive phase I/II trial for newly-diagnosed AML or high-risk MDS patients aged ≥ 50 years using a Bayesian approach to determine whether 1...

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Главные авторы: Lionberger, Jack M., Pagel, John M., Sandhu, Vicky K., Xie, Hu, Shadman, Mazyar, Mawad, Raya, Boehm, Alexandra, Dean, Carol, Shannon-Dorcy, Kathleen, Scott, Bart L., Deeg, H. Joachim, Becker, Pamela S., Hendrie, Paul C., Walter, Roland B., Ostronoff, Fabiana, Appelbaum, Frederick R., Estey, Elihu H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107117/
https://ncbi.nlm.nih.gov/pubmed/24749757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12905
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