Cationic star-shaped polymer as an siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats

BACKGROUND: Excessive expression of matrix metalloproteinase-9 (MMP-9) is deleterious to the cutaneous wound-healing process in the context of diabetes. The aim of the present study was to explore whether a cationic star-shaped polymer consisting of β-cyclodextrin (β-CD) core and poly(amidoamine) de...

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Bibliographic Details
Main Authors: Li, Na, Luo, Heng-Cong, Yang, Chuan, Deng, Jun-Jie, Ren, Meng, Xie, Xiao-Ying, Lin, Diao-Zhu, Yan, Li, Zhang, Li-Ming
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106967/
https://ncbi.nlm.nih.gov/pubmed/25075185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S66368
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