Efficacy of Selective PDE4D Negative Allosteric Modulators in the Object Retrieval Task in Female Cynomolgus Monkeys (Macaca fascicularis)

Cyclic adenosine monophosphate (cAMP) signalling plays an important role in synaptic plasticity and information processing in the hippocampal and basal ganglia systems. The augmentation of cAMP signalling through the selective inhibition of phosphodiesterases represents a viable strategy to treat di...

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Detalhes bibliográficos
Main Authors: Sutcliffe, Jane S., Beaumont, Vahri, Watson, James M., Chew, Chang Sing, Beconi, Maria, Hutcheson, Daniel M., Dominguez, Celia, Munoz-Sanjuan, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106781/
https://ncbi.nlm.nih.gov/pubmed/25050979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102449
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