The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands

Sigma-1 receptor (S1R) is a mammalian member of the ERG2 and sigma-1 receptor-like protein family (pfam04622). It has been implicated in drug addiction and many human neurological disorders, including Alzheimer and Parkinson diseases and amyotrophic lateral sclerosis. A broad range of synthetic smal...

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Main Authors: Gromek, Katarzyna A., Suchy, Fabian P., Meddaugh, Hannah R., Wrobel, Russell L., LaPointe, Loren M., Chu, Uyen B., Primm, John G., Ruoho, Arnold E., Senes, Alessandro, Fox, Brian G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Membrane Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106346/
https://ncbi.nlm.nih.gov/pubmed/24847081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537993
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