Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response

ATP-dependent chromatin remodeling is involved in all DNA transactions and linked to numerous human diseases. We explored functions of chromatin remodelers during cellular aging. Deletion of ISW2, or mutations inactivating the Isw2 enzyme complex, extends yeast replicative lifespan. This extension b...

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Bibliografiset tiedot
Päätekijät: Dang, Weiwei, Sutphin, George L., Dorsey, Jean A., Otte, Gabriel L., Cao, Kajia, Perry, Rocco M., Wanat, Jennifer J., Saviolaki, Dimitra, Murakami, Christopher J., Tsuchiyama, Scott, Robison, Brett, Gregory, Brian D., Vermeulen, Michiel, Shiekhattar, Ramin, Johnson, F. Brad, Kennedy, Brian K., Kaeberlein, Matt, Berger, Shelley L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106248/
https://ncbi.nlm.nih.gov/pubmed/24814484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.04.004
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