Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response

ATP-dependent chromatin remodeling is involved in all DNA transactions and linked to numerous human diseases. We explored functions of chromatin remodelers during cellular aging. Deletion of ISW2, or mutations inactivating the Isw2 enzyme complex, extends yeast replicative lifespan. This extension b...

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Detalhes bibliográficos
Main Authors: Dang, Weiwei, Sutphin, George L., Dorsey, Jean A., Otte, Gabriel L., Cao, Kajia, Perry, Rocco M., Wanat, Jennifer J., Saviolaki, Dimitra, Murakami, Christopher J., Tsuchiyama, Scott, Robison, Brett, Gregory, Brian D., Vermeulen, Michiel, Shiekhattar, Ramin, Johnson, F. Brad, Kennedy, Brian K., Kaeberlein, Matt, Berger, Shelley L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106248/
https://ncbi.nlm.nih.gov/pubmed/24814484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.04.004
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