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Two-photon uncaging of γ-aminobutyric acid in intact brain tissue
We have synthesized a photosensitive (or caged) 4-carboxymethoxy-5,7-dinitroindolinyl (CDNI) derivative of γ-aminobutyric acid (GABA). Two-photon excitation of CDNI-GABA produced rapid activation of GABAergic currents in neurons in brain slices with an axial resolution of approximately 2 micrometers...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104925/ https://ncbi.nlm.nih.gov/pubmed/20173751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.321 |
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