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Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis

Ablation of a single miRNA gene rarely leads to a discernable developmental phenotype in mice, in some cases because of compensatory effects by other functionally related miRNAs. Here, we report that simultaneous inactivation of two functionally related miRNA clusters (miR-34b/c and miR-449) encodin...

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Détails bibliographiques
Auteurs principaux: Wu, Jingwen, Bao, Jianqiang, Kim, Minkyung, Yuan, Shuiqiao, Tang, Chong, Zheng, Huili, Mastick, Grant S., Xu, Chen, Yan, Wei
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104921/
https://ncbi.nlm.nih.gov/pubmed/24982181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407777111
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