Dose Ranging, Expanded Acute Toxicity and Safety Pharmacology Studies for Intravenously Administered Functionalized Graphene Nanoparticle Formulations

Graphene nanoparticles dispersions show immense potential as multifunctional agents for in vivo biomedical applications. Herein, we follow regulatory guidelines for pharmaceuticals that recommend safety pharmacology assessment at least 10 – 100 times higher than the projected therapeutic dose, and p...

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Detalhes bibliográficos
Main Authors: Kanakia, Shruti, Toussaint, Jimmy, Chowdhury, Sayan Mullick, Tembulkar, Tanuf, Lee, Stephen, Jiang, Ya-Ping, Lin, Richard Z., Shroyer, Kenneth R., Moore, William, Sitharaman, Balaji
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104699/
https://ncbi.nlm.nih.gov/pubmed/24854092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.04.066
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