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EphrinA1-EphA2 interaction-mediated apoptosis and Flt3L-induced immunotherapy inhibits tumor growth in a breast cancer mouse model

BACKGROUND: The receptor tyrosine kinase EphA2 is overexpressed in several types of cancers and is currently being pursued as a target for breast cancer therapeutics. The EphA2 ligand EphrinA1 induces EphA2 phosphorylation and intracellular internalization and degradation, thus inhibiting tumor prog...

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Bibliografske podrobnosti
Main Authors: Tandon, Manish, Vemula, Sai V., Sharma, Anurag, Ahi, Yadvinder S., Mittal, Shalini, Bangari, Dinesh S., Mittal, Suresh K.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104612/
https://ncbi.nlm.nih.gov/pubmed/22228563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1649
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