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A “push and slide” mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase

In bacteria, most secretory proteins are translocated across the plasma membrane by the interplay of the SecA ATPase and the SecY channel. How SecA moves a broad range of polypeptide substrates is only poorly understood. Here, we show that SecA moves polypeptides through the SecY channel by a “push...

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Bibliografske podrobnosti
Main Authors: Bauer, Benedikt W., Shemesh, Tom, Chen, Yu, Rapoport, Tom A.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104599/
https://ncbi.nlm.nih.gov/pubmed/24906156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.063
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