Effective suppression of Dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain

INTRODUCTION: Approximately 100 million confirmed infections and 20,000 deaths are caused by Dengue virus (DENV) outbreaks annually. Global warming and rapid dispersal have resulted in DENV epidemics in formally non-endemic regions. Currently no consistently effective preventive measures for DENV ex...

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Main Authors: Carter, James R, Keith, James H, Fraser, Tresa S, Dawson, James L, Kucharski, Cheryl A, Horne, Kate M, Higgs, Stephen, Fraser, Malcolm J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104402/
https://ncbi.nlm.nih.gov/pubmed/24927852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-11-111
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