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Inclusion of a universal tetanus toxoid CD4(+) T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus ΔVP8* subunit parenteral vaccines

Currently available live oral rotavirus vaccines, Rotarix® and RotaTeq®, are highly efficacious in developed countries. However, the immunogenicity and efficacy of such vaccines in some developing countries are low. We reported previously that bacterially-expressed rotavirus ΔVP8* subunit vaccine ca...

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Detalhes bibliográficos
Main Authors: Wen, Xiaobo, Wen, Ke, Cao, Dianjun, Li, Guohua, Jones, Ronald W., Li, Jianping, Szu, Shousun, Hoshino, Yasutaka, Yuan, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104241/
https://ncbi.nlm.nih.gov/pubmed/24962749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.06.060
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