The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder And Amygdala Structure And Function

BACKGROUND: Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide (CO(2)), possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that CO(2)-mediated fear behavior depends on chemosensing of acidosis in the amygdala v...

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Библиографические подробности
Главные авторы: Smoller, Jordan W., Gallagher, Patience J., Duncan, Laramie E., McGrath, Lauren M., Haddad, Stephen A., Holmes, Avram., Wolf, Aaron B., Hilker, Sidney, Block, Stefanie R., Weill, Sydney, Young, Sarah, Choi, Eun Young, Rosenbaum, Jerrold F., Biederman, Joseph, Faraone, Stephen V., Roffman, Joshua, Manfro, Gisele G., Blaya, Carolina, Hirshfeld-Becker, Dina R., Stein, Murray B., Van Ameringen, Michael, Tolin, David F., Otto, Michael W., Pollack, Mark H., Simon, Naomi M., Buckner, Randy L., Ongur, Dost, Cohen, Bruce M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103972/
https://ncbi.nlm.nih.gov/pubmed/24529281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.12.018
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