Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene

In diabetics, methylglyoxal (MG), a glucose-derived metabolite, plays a noxious role by inducing oxidative stress, which causes and exacerbates a series of complications including low-turnover osteoporosis. In the present study, while MG treatment of mouse bone marrow stroma-derived ST2 cells rapidl...

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Main Authors: Mori, Kiyoshi, Kitazawa, Riko, Kondo, Takeshi, Mori, Michiko, Hamada, Yasuhiro, Nishida, Michiru, Minami, Yasuhiro, Haraguchi, Ryuma, Takahashi, Yutaka, Kitazawa, Sohei
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103869/
https://ncbi.nlm.nih.gov/pubmed/25036934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102797
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