Safeguarding Stem Cell-Based Regenerative Therapy against Iatrogenic Cancerogenesis: Transgenic Expression of DNASE1, DNASE1L3, DNASE2, DFFB Controlled By POLA1 Promoter in Proliferating and Directed Differentiation Resisting Human Autologous Pluripotent Induced Stem Cells Leads to their Death

INTRODUCTION: The worst possible complication of using stem cells for regenerative therapy is iatrogenic cancerogenesis. The ultimate goal of our work is to develop a self-triggering feedback mechanism aimed at causing death of all stem cells, which resist directed differentiation, keep proliferatin...

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Detalhes bibliográficos
Main Authors: Malecki, Marek, LaVanne, Christine, Alhambra, Dominique, Dodivenaka, Chaitanya, Nagel, Sarah, Malecki, Raf
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103669/
https://ncbi.nlm.nih.gov/pubmed/25045589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2157-7633.S9-005
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