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Deconvolving tumor purity and ploidy by integrating copy number alterations and loss of heterozygosity
Motivation: Next-generation sequencing (NGS) has revolutionized the study of cancer genomes. However, the reads obtained from NGS of tumor samples often consist of a mixture of normal and tumor cells, which themselves can be of multiple clonal types. A prominent problem in the analysis of cancer gen...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4103592/ https://ncbi.nlm.nih.gov/pubmed/24695406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu174 |
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