Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones

Expression or introduction of the neuropeptide substance-P (SP; encoded by the TAC1 gene in humans and Tac1 in rodents) in the amygdala induces anxiety related behaviour in rodents. In addition, pharmacological antagonism of the main receptor of SP in humans; NK1, is anxiolytic. In the current study...

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Main Authors: Hay, Colin W., Shanley, Lynne, Davidson, Scott, Cowie, Philip, Lear, Marissa, McGuffin, Peter, Riedel, Gernot, McEwan, Iain J., MacKenzie, Alasdair
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103484/
https://ncbi.nlm.nih.gov/pubmed/25001955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2014.04.017
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