Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB

BACKGROUND: Glyoxalase I (GI) is a cellular defence enzyme involved in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis, and MG-derived advanced glycation end products (AGEs). Argpyrimidine (AP), one of the major AGEs coming from MG modifications of proteins arginines, i...

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Detalhes bibliográficos
Main Authors: Antognelli, C, Palumbo, I, Aristei, C, Talesa, V N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102940/
https://ncbi.nlm.nih.gov/pubmed/24918814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.280
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