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Next Generation Sequencing Reveals Skewing of the T and B Cell Receptor Repertoires in Patients with Wiskott–Aldrich Syndrome

The Wiskott–Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein, leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR and BCR). We hypothesized that the impaired signaling through the TCR and BCR in WAS would subs...

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Bibliografiska uppgifter
Huvudupphovsmän: O’Connell, Amy E., Volpi, Stefano, Dobbs, Kerry, Fiorini, Claudia, Tsitsikov, Erdyni, de Boer, Helen, Barlan, Isil B., Despotovic, Jenny M., Espinosa-Rosales, Francisco J., Hanson, I. Celine, Kanariou, Maria G., Martínez-Beckerat, Roxana, Mayorga-Sirera, Alvaro, Mejia-Carvajal, Carmen, Radwan, Nesrine, Weiss, Aaron R., Pai, Sung-Yun, Lee, Yu Nee, Notarangelo, Luigi D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102881/
https://ncbi.nlm.nih.gov/pubmed/25101082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00340
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