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IRE1α knockdown rescues tunicamycin-induced developmental defects and apoptosis in Xenopus laevis
Inositol requiring enzyme-1 (IRE1) is highly conserved from yeasts to humans. Upon endoplasmic reticulum (ER) stress, IRE1 activates X-box-binding protein 1 (XBP1) by unconventional splicing of XBP1 mRNA, which activates unfolded protein response (UPR) to restore ER homeostasis. In mice, IRE1α plays...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Editorial Department of Journal of Biomedical Research
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4102841/ https://ncbi.nlm.nih.gov/pubmed/25050111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7555/JBR.28.20120075 |
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