T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exhaustion in part through direct modulation of PD-1....

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Hlavní autoři: Buggert, Marcus, Tauriainen, Johanna, Yamamoto, Takuya, Frederiksen, Juliet, Ivarsson, Martin A., Michaëlsson, Jakob, Lund, Ole, Hejdeman, Bo, Jansson, Marianne, Sönnerborg, Anders, Koup, Richard A., Betts, Michael R., Karlsson, Annika C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102564/
https://ncbi.nlm.nih.gov/pubmed/25032686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004251
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