Effects of Exogenous Recombinant APC in Mouse Models of Ischemia Reperfusion Injury and of Atherosclerosis

Activated protein C (APC) is a serine protease that has both anticoagulant and cytoprotective properties. The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C receptor (EPCR) dependent and likely underlie protective effects of APC in animal models of sepsis,...

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Detalhes bibliográficos
Main Authors: Wildhagen, Karin C. A. A., Schrijver, Roy, Beckers, Linda, ten Cate, Hugo, Reutelingsperger, Chris P. M., Lutgens, Esther, Nicolaes, Gerry A. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102480/
https://ncbi.nlm.nih.gov/pubmed/25032959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101446
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