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Peptide inhibitors of peptidyltransferase alter the conformation of domains IV and V of large subunit rRNA: a model for nascent peptide control of translation.

Peptides of 5 and 8 residues encoded by the leaders of attenuation regulated chloramphenicol-resistance genes inhibit the peptidyltransferase of microorganisms from the three kingdoms. Therefore, the ribosomal target for the peptides is likely to be a conserved structure and/or sequence. The inhibit...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Harrod, R, Lovett, P S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1995
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41024/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7567991/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8650
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