Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression

Immune system defects are at the center of aging and a range of diseases. Here we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSC) and niche cells that prom...

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Detalhes bibliográficos
Main Authors: Cheng, Chia-Wei, Adams, Gregor B., Perin, Laura, Wei, Min, Zhou, Xiaoying, Lam, Ben S., Da Sacco, Stefano, Mirisola, Mario, Quinn, David I., Dorff, Tanya B., Kopchick, John J., Longo, Valter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102383/
https://ncbi.nlm.nih.gov/pubmed/24905167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.04.014
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