Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggest novel combinatorial approaches for enhancing responses

Combinatorial HIV/SIV vaccine approaches targeting multiple arms of the immune system might improve protective efficacy. We compared SIV-specific humoral immunity induced in rhesus macaques by five vaccine regimens. Systemic regimens included ALVAC-SIVenv priming and Env boosting (ALVAC/Env); DNA im...

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Main Authors: Vargas-Inchaustegui, Diego A., Tuero, Iskra, Mohanram, Venkatramanan, Musich, Thomas, Pegu, Poonam, Valentin, Antonio, Sui, Yongjun, Rosati, Margherita, Bear, Jenifer, Venzon, David J., Kulkarni, Viraj, Alicea, Candido, Pilkington, Guy R., Liyanage, Namal P.M., Demberg, Thorsten, Gordon, Shari N., Wang, Yichuan, Hogg, Alison E., Frey, Blake, Patterson, L. Jean, DiPasquale, Janet, Montefiori, David C., Sardesai, Niranjan Y., Reed, Steven G., Berzofsky, Jay A., Franchini, Genoveffa, Felber, Barbara K., Pavlakis, George N., Robert-Guroff, Marjorie
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102324/
https://ncbi.nlm.nih.gov/pubmed/24907411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.05.008
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