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Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations

An unresolved question about GPCR function is the role of membrane components in receptor stability and activation. In particular, cholesterol is known to affect the function of membrane proteins, but the details of its effect on GPCRs are still elusive. Here, we describe how cholesterol modulates t...

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Bibliografische gegevens
Hoofdauteurs: Khelashvili, George, Grossfield, Alan, Feller, Scott E., Pitman, Michael C., Weinstein, Harel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101808/
https://ncbi.nlm.nih.gov/pubmed/19173312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22355
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