Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids

Reduced AMP kinase (AMPK) activity has been shown to play a key deleterious role in increased hepatic gluconeogenesis in diabetes, but the mechanism whereby this occurs remains unclear. In this article, we document that another AMP-dependent enzyme, AMP deaminase (AMPD) is activated in the liver of...

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Detalhes bibliográficos
Main Authors: Cicerchi, Christina, Li, Nanxing, Kratzer, James, Garcia, Gabriela, Roncal-Jimenez, Carlos A., Tanabe, Katsuyuki, Hunter, Brandi, Rivard, Christopher J., Sautin, Yuri Y., Gaucher, Eric A., Johnson, Richard J., Lanaspa, Miguel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101654/
https://ncbi.nlm.nih.gov/pubmed/24755741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-243634
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