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Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells

Men with sickle cell disease (SCD) risk developing priapism. Recognizing that SCD is a disease of hypoxia, we investigated the effect of hypoxia on gene expression in corporal smooth muscle (CSM) cells. Rat CSM cells in vitro were treated with CoCl(2) or low oxygen tension to mimic hypoxia. Hypoxic...

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Autori principali: Fu, Shibo, Tar, Moses Tarndie, Melman, Arnold, Davies, Kelvin Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101653/
https://ncbi.nlm.nih.gov/pubmed/24803544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-248708
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