Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells

Men with sickle cell disease (SCD) risk developing priapism. Recognizing that SCD is a disease of hypoxia, we investigated the effect of hypoxia on gene expression in corporal smooth muscle (CSM) cells. Rat CSM cells in vitro were treated with CoCl(2) or low oxygen tension to mimic hypoxia. Hypoxic...

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Bibliographic Details
Main Authors: Fu, Shibo, Tar, Moses Tarndie, Melman, Arnold, Davies, Kelvin Paul
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2014
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101653/
https://ncbi.nlm.nih.gov/pubmed/24803544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-248708
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