PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells()()

The synergistic targeting of DNA damage and DNA repair is a promising strategy for the development of new chemotherapeutic agents for human lung cancer. The DNA interstrand cross-linking agent BO-1509, a derivative of 3a-aza-cyclopenta[α]indene, was synthesized and combined with the phosphoinositide...

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Hauptverfasser: Sanjiv, Kumar, Chen, Chi-Wei, Kakadiya, Rajesh, Tala, Satishkumar, Suman, Sharda, Wu, Ming-Hsi, Chen, Yen-Hui, Su, Tsann-Long, Lee, Te-Chang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101349/
https://ncbi.nlm.nih.gov/pubmed/24913674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2014.02.012
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