Evolutionary Divergence in the Catalytic Activity of the CAM-1, ROR1 and ROR2 Kinase Domains

Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases. The vertebrate RORs contain an ATP binding domain that deviates from the consensus amino acid sequence, although the im...

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Auteurs principaux: Bainbridge, Travis W., DeAlmeida, Venita I., Izrael-Tomasevic, Anita, Chalouni, Cécile, Pan, Borlan, Goldsmith, Joshua, Schoen, Alia P., Quiñones, Gabriel A., Kelly, Ryan, Lill, Jennie R., Sandoval, Wendy, Costa, Mike, Polakis, Paul, Arnott, David, Rubinfeld, Bonnee, Ernst, James A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100928/
https://ncbi.nlm.nih.gov/pubmed/25029443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102695
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