Multi-Tissue Computational Modeling Analyzes Pathophysiology of Type 2 Diabetes in MKR Mice

Computational models using metabolic reconstructions for in silico simulation of metabolic disorders such as type 2 diabetes mellitus (T2DM) can provide a better understanding of disease pathophysiology and avoid high experimentation costs. There is a limited amount of computational work, using meta...

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Main Authors: Kumar, Amit, Harrelson, Thomas, Lewis, Nathan E., Gallagher, Emily J., LeRoith, Derek, Shiloach, Joseph, Betenbaugh, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100879/
https://ncbi.nlm.nih.gov/pubmed/25029527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102319
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