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QnrS1 structure–activity relationships

OBJECTIVES: Loop B is important for low-level quinolone resistance conferred by Qnr proteins. The role of individual amino acids within QnrS1 loop B in quinolone resistance and gyrase protection was assessed. METHODS: qnrS1 and 11 qnrS1 alleles with site-directed Ala mutations in loop B were express...

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Hlavní autoři: Tavío, María M., Jacoby, George A., Hooper, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100707/
https://ncbi.nlm.nih.gov/pubmed/24729602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku102
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