Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms

OBJECTIVE: Male sex is a non-modifiable risk factor for abdominal aortic aneurysm (AAA) development. Similar to humans, male mice are more susceptible to angiotensin II (AngII)-induced AAAs than females. Previous studies demonstrated that castration of males markedly reduced the formation of AngII-i...

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Bibliographic Details
Main Authors: Zhang, Xuan, Thatcher, Sean, Wu, Congqing, Daugherty, Alan, Cassis, Lisa A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099302/
https://ncbi.nlm.nih.gov/pubmed/24439319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvs.2013.11.004
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