Structural Integrity of the Antigen Is a Determinant for the Induction of T-Helper Type-1 Immunity in Mice by Gene Gun Vaccines against E.coli Beta-Galactosidase

The type of immune response is critical for successful protection and typically determined by pathogen-associated danger molecules. In contrast, protein antigens are usually regarded as passive target structures. Here, we provide evidence that the structure of the antigen can profoundly influence th...

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Detalhes bibliográficos
Main Authors: Deressa, Tekalign, Stoecklinger, Angelika, Wallner, Michael, Himly, Martin, Kofler, Stefan, Hainz, Katrina, Brandstetter, Hans, Thalhamer, Josef, Hammerl, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099185/
https://ncbi.nlm.nih.gov/pubmed/25025197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102280
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