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Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II

Malondialdehyde, a genotoxic byproduct of lipid peroxidation, reacts with guanine in DNA to form pyrimido[1,2-α]purin-10(3H)one (M(1)dG), the first endogenous DNA lesion found to be a target of nucleotide excision repair enzymes. A subpathway of nucleotide excision repair, transcription-coupled repa...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cline, Susan D., Riggins, James N., Tornaletti, Silvia, Marnett, Lawrence J., Hanawalt, Philip C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409909/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15123825/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402252101
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