Splicing biomarkers of disease severity in myotonic dystrophy

OBJECTIVE: To develop RNA splicing biomarkers of disease severity and therapeutic response in myotonic dystrophy type 1 (DM1) and type 2 (DM2). METHODS: In a discovery cohort we used microarrays to perform global analysis of alternative splicing in DM1 and DM2. The newly identified splicing changes...

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Main Authors: Nakamori, Masayuki, Sobczak, Krzysztof, Puwanant, Araya, Welle, Steve, Eichinger, Katy, Pandya, Shree, Dekdebrun, Jeannne, Heatwole, Chad R., McDermott, Michael P., Chen, Tian, Cline, Melissa, Tawil, Rabi, Osborne, Robert J., Wheeler, Thurman M., Swanson, Maurice, Moxley, Richard T., Thornton, Charles A.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099006/
https://ncbi.nlm.nih.gov/pubmed/23929620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23992
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