Cytotoxic potential of lung CD8+ T cells increases with COPD severity and with in vitro stimulation by IL-18 or IL-15

Lung CD8+ T cells might contribute to progression of chronic obstructive pulmonary disease (COPD) indirectly via IFN-γ production or directly via cytolysis but evidence for either mechanism is largely circumstantial. To gain insights into these potential mechanisms, we analyzed clinically-indicated...

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Detalhes bibliográficos
Main Authors: Freeman, Christine M., Han, MeiLan K., Martinez, Fernando J., Murray, Susan, Liu, Lyrica X., Chensue, Stephen W., Polak, Timothy J., Sonstein, Joanne, Todt, Jill C., Ames, Theresa M., Arenberg, Douglas A., Meldrum, Catherine A., Getty, Christi, McCloskey, Lisa, Curtis, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098931/
https://ncbi.nlm.nih.gov/pubmed/20427767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000006
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