Directed Evolution of an LBP/CD14 Inhibitory Peptide and Its Anti-Endotoxin Activity

BACKGROUND: LPS-binding protein (LBP) and its ligand CD14 are located upstream of the signaling pathway for LPS-induced inflammation. Blocking LBP and CD14 binding might prevent LPS-induced inflammation. In previous studies, we obtained a peptide analog (MP12) for the LBP/CD14 binding site and showe...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Fang, Li, Xu, Zhi, Wang, Guan-song, Ji, Fu-yun, Mei, Chun-xia, Liu, Juan, Wu, Guo-ming
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098906/
https://ncbi.nlm.nih.gov/pubmed/25025695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101406
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