Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells

Previous investigations revealed low activities of lactate dehydrogenase (LDH) and plasma membrane monocarboxylate transporters (MCT) in the pancreatic β cell. In this study the significance of these characteristics was explored by overexpressing type A LDH (LDH-A) and/or type 1 MCT (MCT-1) in the c...

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Bibliographic Details
Main Authors: Ishihara, Hisamitsu, Wang, Haiyan, Drewes, Lester R., Wollheim, Claes B.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC409861/
https://ncbi.nlm.nih.gov/pubmed/10587526
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