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A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells

Goblet cells are the major mucus-producing cells of the intestine and are presumed to play an important role in mucosal protection. However, their functional role has not been directly assessed in vivo. In initial studies, a 5′ flanking sequence of the murine intestinal trefoil factor (ITF) gene was...

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Bibliografiske detaljer
Main Authors: Itoh, Hiroshi, Beck, Paul L., Inoue, Nagamu, Xavier, Ramnik, Podolsky, Daniel K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC409855/
https://ncbi.nlm.nih.gov/pubmed/10587517
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