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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of aging. There is ample evidence that escape fro...

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Main Authors: Dimri, G P, Lee, X, Basile, G, Acosta, M, Scott, G, Roskelley, C, Medrano, E E, Linskens, M, Rubelj, I, Pereira-Smith, O
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC40985/
https://ncbi.nlm.nih.gov/pubmed/7568133
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