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Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

It was recently shown that naturally occurring Mdr1a mutant fetuses of the CF-1 outbred mouse stock have no placental Mdr1a P-glycoprotein (P-gp) and that this absence is associated with increased sensitivity to avermectin, a teratogenic pesticide. To further define the role of placental drug-transp...

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Udgivet i:J Clin Invest
Principais autores: Smit, Johan W., Huisman, Maarten T., van Tellingen, Olaf, Wiltshire, Hugh R., Schinkel, Alfred H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409845/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10562306/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7963
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