Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that stimulates the hypothalamo-pituitary-adrenal (HPA) axis through JAK-STAT activation. We show here that LIF-induced JAK2 and STAT3 tyrosine phosphorylation is transient, disappearing within 20 and 40 minutes, respectively. LIF activates...

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Bibliographic Details
Main Authors: Bousquet, Corinne, Susini, Christiane, Melmed, Shlomo
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC409825/
https://ncbi.nlm.nih.gov/pubmed/10545526
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